Corneal ulceration in Tanzanian children: relationship between malaria and herpes simplex keratitis
Abstract
Two 3-year prospective studies from 1982–1984 and 1986–1988 in Tanzania identified 189 children with corneal ulceration, of whom 92 (48 · 7%) were due to herpes simplex keratitis. In 1982–1984 herpes simplex keratitis was responsible for 35 · 5% of corneal ulcers (38 of 107), compared with 65 · 8% (54 of 82) in 1986–1988 (P = 0 · 00006). It is postulated that the increase in corneal ulceration due to herpes simplex keratitis can be attributed to an increase in the incidence and severity of malaria infection.
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