ANAPLASMOOSI punkin puremasta!
. 2022 Sep;36(3):639-654.
doi: 10.1016/j.idc.2022.02.008. Human Granulocytic Anaplasmosis
Affiliations PMID:
36116840 DOI:
10.1016/j.idc.2022.02.008
Abstract uman granulocytic anaplasmosis (HGA) is a bacterial infection
caused by Anaplasma phagocytophilum and transmitted by the bite of the
black-legged (deer tick) in North America. Its incidence is increasing.
HGA can be transmitted after 24 to 48 hours of tick attachment. The
incubation period is 5 to 14 days after a tick bite. Symptoms include
fever, chills, headache, and myalgia. Complications include shock, organ
dysfunction, and death. Mortality is less than 1% with appropriate
treatment. Doxycycline is first line treatment for all ages. Start it
empirically if symptoms and risk factors suggest HGA. PCR is the
confirmatory test of choice.Keywords:
Anaplasmosis; Deer tick; Doxycycline; Ixodes; Leukopenia; Thrombocytopenia; Tick-borne.Copyright © 2022 Elsevier Inc. All rights reserved.
TAXONOMY: deer tick; Ixodes pacificus (western blacklegged tick)
Ananplasma phagocytophilum . on zoonoottinen obligatorisesti intracellulaarinen bakteeri, jota välittyy myös Siberian taiga-punkin kautta (Ixoides persulcatuus)
LÄHDE:
Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives.
Front Cell Infect Microbiol. 2015 Aug 14;5:61. doi: 10.3389/fcimb.2015.00061. eCollection 2015.
PMID: 26322277
Free PMC article.
Review.
Anaplasma phagocytophilum is a
zoonotic obligate intracellular bacterium known to be transmitted by
ticks belonging to the Ixodes persulcatus complex. ...Here, we review
the current knowledge and future perspectives regarding A. phagocytophilum epidemiology a …
This
bacterium can infect several mammalian species, and is known to cause
diseases with variable symptoms in many domestic animals. Specifically,
it is the causative agent of tick-borne fever (TBF), a disease of
important economic impact in European domestic ruminants, and human
granulocytic anaplasmosis (HGA), an emerging zoonotic disease in Asia,
USA and Europe. A. phagocytophilum epidemiological cycles are complex
and involve different ecotypes, vectors, and mammalian host species.
Moreover, the epidemiology of A. phagocytophilum infection differs
greatly between Europe and the USA. These different epidemiological
contexts are associated with considerable variations in bacterial
strains. Until recently, few A. phagocytophilum molecular typing tools
were available, generating difficulties in completely elucidating the
epidemiological cycles of this bacterium. Over the last few years, many
A. phagocytophilum typing techniques have been developed, permitting
in-depth epidemiological exploration. Here, we review the current
knowledge and future perspectives regarding A. phagocytophilum
epidemiology and phylogeny, and then focus on the molecular typing tools
available for studying A. phagocytophilum genetic diversity.
Keywords: Anaplasma phagocytophilum; diversity; epidemiology; granulocytic anaplasmosis; phylogeny; tick-borne fever; typing technique.
Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism.
Front Cell Infect Microbiol. 2022 May 26;12:828605. doi: 10.3389/fcimb.2022.828605. eCollection 2022.
PMID: 35719343
Free PMC article.
Anaplasma phagocytophilum, a
tick-borne obligately intracellular bacterium of neutrophils, causes
human granulocytic anaplasmosis. ...However, AnkA nuclear localization
was also decreased with importazole, and with GTPgammaS. Furthermore, A.
phagocytophilum g …
Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum.
Clin Microbiol Rev. 2011 Jul;24(3):469-89. doi: 10.1128/CMR.00064-10.
PMID: 21734244
Free PMC article.
Review.
Anaplasma phagocytophilum persists in nature by cycling between mammals and ticks. ...A. phagocytophilum evolved the remarkable ability to hijack the regulatory system of host cells.
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