Challenges in the Diagnosis and Treatment of Lyme Disease.
Curr Rheumatol Rep. 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2.
PMID: 31912251
Review.
The purpose of this review is to examine advances in the diagnosis and treatment of Lyme disease, as well as ongoing management challenges. RECENT FINDINGS: Recent findings:
It is useful to recognize that Lyme disease occurs in stages, with
early- and late-stage disease. Clinical expression is in part
determined by Borrelial variability. For example, some strains of
Borrelia burgdorferi, the causative organism in North America, are
particularly arthritogenic. Most patients with early Lyme disease can be
cured with a single course of oral antibiotic therapy, in contrast to
some patients with Lyme arthritis, a late-stage manifestation, who are
more antibiotic refractory and require other treatment strategies.
Successful treatment of Lyme disease begins with successful diagnosis
and with an understanding of the emergence, clinical features, and
impact of Lyme disease over the past half century.
A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist.
Clin Rev Allergy Immunol. 2022 Feb;62(1):264-271. doi: 10.1007/s12016-021-08906-w. Epub 2021 Oct 23.
PMID: 34687445
Review.
The constellation of symptoms such as fatigue, cognitive
dysfunction, and musculoskeletal pain that persist beyond 6 months and
are associated with disability have been termed post-treatment Lyme disease syndrome (PTLDS), a subset of a broader term "chronic Lyme …
Infect Dis Clin North Am. 2022 Sep;36(3):593-603. doi: 10.1016/j.idc.2022.03.002.
PMID: 36116837
Review.
DOI:
10.1016/j.idc.2022.03.002
Abstract
Lyme disease is now the most frequently reported vector-borne
disease in the United States. The highest incidence is in children aged 5
to 9 years with a male predominance. The most common manifestation,
erythema migrans, is sometimes not recognized, leading to risk of
complications. Testing for Lyme disease should only be done if there is a
consistent clinical syndrome with exposure in a Lyme-endemic area. Most
forms of Lyme disease are successfully treated with short courses of
oral therapy. Prevention and management of tick bites is important. Keywords:
Child; Intracranial hypertension; Lyme disease; Tick bites; Tick-borne diseases.
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