Kehon antimikrobiaalinenn vaste E.Coli bakteerille

Experimental Physiology

• Experimental Physiology (2001), 86: 543-545
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• DOI: doi:10.1113/eph8602250 (About DOI)
• Published online: 24 September 2001

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Table of Contents - 2001 - Volume 86, Issue 05

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Rapid Communications Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect K. Marutsuka a1, Y. Nawa a2, Y. Asada a1, S. Hara a4, K. Kitamura a4, T. Eto a4 and A. Sumiyoshi a1 a1 First Department of Pathology, a2 Department of Parasitology and a4 First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan Abstract The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence. Experimental Physiology (2001) 86.5, 543-545. (Received May 2 2001) (Accepted June 29 2001)