J Leukoc Biol. 2017 Apr;101(4):841-849. doi: 10.1189/jlb.3MR0916-380R. Epub 2016 Dec 20.
Inflammasome biology taught by Legionella pneumophila.
Inflammasomes
are multimeric protein complexes that assemble in the cytosol of many
types of cells, including innate immune cells. The inflammasomes can be
activated in response to infection or in response to stress signals that
induce damage in the host cell membranes.
These platforms trigger inflammatory processes, cell death, and the control of microbial replication. Many inflammasomes have been described so far, including
By contrast, inflammasomes, such as those composed of NAIP/NLRC4, caspase-11, and AIM2, can be activated by bacterial flagellin, LPS, and dsDNA.
The knowledge of inflammasome biology has advanced tremendously in the last decade, fostered by the use of model organisms, such as Legionella pneumophila This bacterium evolved, infecting unicellular protozoa in freshwater environments, and the human infection is accidental.
Thus, L. pneumophila did not evolve sophisticated mechanisms to inhibit mammalian innate immunity.
For this reason, it has emerged as a very appropriate model of a pathogenic microbe for the investigation of inflammasome biology.
In this review, we highlight the current information regarding the biology of inflammasomes and emphasize the advances achieved using L. pneumophila
We also describe the inflammasomes activated in response to L. pneumophila infection and discuss the effector mechanisms that operate to clear the infection.
These platforms trigger inflammatory processes, cell death, and the control of microbial replication. Many inflammasomes have been described so far, including
- NLRP3,
- NAIP/NLRC4,
- caspase-11, and
- AIM2 (absent in n melanoma 2)Preferred Names
- interferon-inducible protein AIM2
By contrast, inflammasomes, such as those composed of NAIP/NLRC4, caspase-11, and AIM2, can be activated by bacterial flagellin, LPS, and dsDNA.
The knowledge of inflammasome biology has advanced tremendously in the last decade, fostered by the use of model organisms, such as Legionella pneumophila This bacterium evolved, infecting unicellular protozoa in freshwater environments, and the human infection is accidental.
Thus, L. pneumophila did not evolve sophisticated mechanisms to inhibit mammalian innate immunity.
For this reason, it has emerged as a very appropriate model of a pathogenic microbe for the investigation of inflammasome biology.
In this review, we highlight the current information regarding the biology of inflammasomes and emphasize the advances achieved using L. pneumophila
We also describe the inflammasomes activated in response to L. pneumophila infection and discuss the effector mechanisms that operate to clear the infection.
KEYWORDS:
AIM2;ASC;
NLRC4;
NLRP3;
caspase-1;
caspase-11
- PMID:
- 27999148
- DOI:
- 10.1189/jlb.3MR0916-380R
- [Indexed for MEDLINE]
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